Gastric O-acyl transferase activates hunger signal to the brain
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چکیده
منابع مشابه
Ghrelin O-Acyl Transferase: Bridging Ghrelin and Energy Homeostasis
Ghrelin O-acyl transferase (GOAT) is a recently identified enzyme responsible for the unique n-acyl modification of ghrelin, a multifunctional metabolic hormone. GOAT structure and activity appears to be conserved from fish to man. Since the acyl modification is critical for most of the biological actions of ghrelin, especially metabolic functions, GOAT emerged as a very important molecule of i...
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Jun Zhang, Sonia L. Planey, Carolina Ceballos, Stanley M. Stevens Jr. Susan K. Keay, and David A. Zacharias 1 The Whitney Laboratory, Department of Neuroscience, University of Florida, St. Augustine, Florida 32080 2. Proteomics Core Facility, ICBR, University of Florida, Gainesville, Florida, 32610 3. University of Maryland, VA Medical Center, Baltimore, MD 21201 Running Title: Palmitoyl Acyl T...
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Gastric distention during meal ingestion activates vagal afferents, which send signals from the stomach to the brain and result in the perception of fullness and satiety. Distention is one of the mechanisms that modulates food intake. We measured regional brain activation during dynamic gastric balloon distention in 18 health subjects using functional magnetic resonance imaging and the blood ox...
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Ghrelin acts as an endocrine link connecting physiological processes regulating food intake, body composition, growth, and energy balance. Ghrelin is the only peptide known to undergo octanoylation. The enzyme mediating this process, ghrelin O-acyltransferase (GOAT), is expressed in the gastrointestinal tract (GI; primary source of circulating ghrelin) as well as other tissues. The present stud...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0802461105